MARC details
| 000 -LEADER |
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| fixed length control field |
02369nam a2200301Ia 4500 |
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02813naaa 00373uu |
| 001 - CONTROL NUMBER |
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https://directory.doabooks.org/handle/20.500.12854/53229 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20211222141608.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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211013s9999 xx 000 0 und d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
978-2-88945-253-8 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.3389/978-2-88945-253-8 |
| 042 ## - AUTHENTICATION CODE |
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| Authentication code |
dc |
| 245 #4 - TITLE STATEMENT |
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| Title |
The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Name of publisher, distributor, etc. |
Frontiers Media SA |
| Date of publication, distribution, etc. |
2017 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
1 electronic resource (161 p.) |
| 506 ## - RESTRICTIONS ON ACCESS NOTE |
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| Terms governing access |
Open Access |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Impairment of energy metabolism is a hallmark of brain aging and several neurodegenerative diseases, such as the Alzheimer's disease (AD). Age- and disease-related hypometabolism is commonly associated with oxidative stress and they are both regarded as major contributors to the decline in synaptic plasticity and cognition. Neuroinflammatory changes, entailing microglial activation and elevated expression of inflammatory cytokines, also correlate with age-related cognitive decline. It is still under debate whether the mitochondrial dysfunction-induced metabolic deficits or the microglia activation-mediated neuroinflammation is the initiator of the cognitive changes in aging and AD. Nevertheless, multiple lines of evidence support the notion that mitochondrial dysfunction and chronic inflammation exacerbate each other, and these mechanistic diversities have cellular redox dysregulation as a common denominator. This research topic focuses on the role of a metabolic-inflammatory axis encompassing the bioenergetic activity, brain inflammatory responses and their redox regulation in healthy brain aging and neurodegenerative diseases. Dynamic interactions among these systems are reviewed in terms of their causative or in-tandem occurrence and how the systemic environment, -e.g., insulin resistance, diabetes, and systemic inflammation-, impacts on brain function. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE |
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| Terms governing use and reproduction |
Creative Commons |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Brain aging |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Enrique Cadenas |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Fei Yin |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Jia Yao |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Roberta Diaz Brinton |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://journal.frontiersin.org/researchtopic/2807/the-metabolic-inflammatory-axis-in-brain-aging-and-neurodegeneration">http://journal.frontiersin.org/researchtopic/2807/the-metabolic-inflammatory-axis-in-brain-aging-and-neurodegeneration</a> |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://directory.doabooks.org/handle/20.500.12854/53229">https://directory.doabooks.org/handle/20.500.12854/53229</a> |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="www.oapen.org">www.oapen.org</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
E-Book |
