TY  - BOOK
AU  - Stark,Holger
TI  - Histamine H4 receptor: a Novel Drug Target For Immunoregulation and Inflammation 
SN  - 9788376560564
AV  - QP801.H5 .S73 2013eb
U1  - 616.97 
PY  - 2013///]
CY  - Warsaw, Berlin : 
PB  - De Gruyter Open Poland, 
KW  - Histamine
KW  - Life Sciences
KW  - Life sciences
KW  - Molecular Biology
KW  - Asthma
KW  - Autoimmune Disorders
KW  - G protein coupled receptors
KW  - H4R ligands
KW  - Inflammation
KW  - Pruritus
KW  - SCIENCE / Chemistry / General
KW  - bisacsh
KW  - G protein coupled receptors, H4R ligands, Inflammation, Autoimmune Disorders, Pruritus, Asthma, Allergy, Cancer, Drug Development, Drug Target, Clinical Candidates, Biogenic Amin
N1  - Frontmatter --; Contents --; Preface --; Chapter 1 The histamine H4 receptor story --; Chapter 2 Histamine H4 Receptor Ligands --; Chapter 3 Histamine Metabolism --; Chapter 4 Histamine Receptors and Inflammatory Cells --; Chapter 5 Histamine in Asthmatic and Fibrotic Lung Disorders --; Chapter 6 Histamine in Atopic Disorders: Atopic Dermatitis and Pruritus --; Chapter 7 Non-professional Histamine Producing Cells, Immune Responses and Autoimmunity --; Chapter 8 Histamine in Cancer --; Chapter 9 Non Receptor-mediated Histamine Actions --; Chapter 10 Perspectives in H4R Research and Therapeutic Exploitation --; List of Figures --; List of Tables --; Index; Open Access
N2  - H4 R is the newest member of the histamine receptor family, which was discovered about twelve years ago. It is considered a very promising drug target. The effort to improve the pharmacokinetic properties of the currently available H4 R ligands is reflected in a steadily growing number of scientific publications and patent applications. Preclinical data strongly confirms the need for novel potent H4 R ligands to explore their therapeutic value in allergy, inflammation, autoimmune disorders, and possibly, cancer. Readers will be provided with extensive knowledge on histamine metabolism, as well as cellular histamine transport, storage and release, effects of histamine and histamine receptor ligands, with particular attention to the H4 R, on inflammatory cells including mast cells, basophils, eosinophils, neutrophils, macrophages, dendritic cells, and T cells. The present knowledge on the regulatory role of histamine and the therapeutic exploitation of histamine receptor ligands in atopic diseases, with emphasis on human and animal models of asthma, allergic dermatitis and pruritus are discussed
UR  - https://doi.org/10.2478/9788376560564
UR  - https://www.degruyter.com/isbn/9788376560564
UR  - https://www.degruyter.com/cover/covers/9788376560564.jpg
ER  -