Comparative analysis on the hepatoprotective activity of mikania Jhumerzon A. Macanda... [et. al]

Thesis (Bachelor of Science in Biology) -- University of Rizal System-Morong.

EXECUTIVE SUMMARY: This study aimed to determine and compare the hepatoprotective activity of Mikania cordata (Burm.f.) B.L. Robins (Bikas) Roots Extract and Premna odorata Blanco (Alagaw) Leaves Extract by determining the blood serum levels of Serum Glutamic-Pyruvic Transaminase (SGPT) Serum Glutamic Oxaloacetic Transaminase (SGOT), and Alkaline Phosphatase (ALP). It was conducted at the University of Rizal System Morong Campus during the School Year 2017-2018. Further, the study was conducted in order to explore and utilize native plants and determine its usage in herbal medicine such as Bikas and Alagaw. Bikas is a smooth vine that contains flavonoid, steroids, alkaloid, tannin, gum, saponin, stigma sterol, beta-sitosterol, sesquiterpene dilactones, mikanolide, dihyrdomikanolide and scandenolide that can be used as hepatoprotective agent. While Alagaw is a small hairy tree that possessed sudorific, pectoral, carminative that has shown hepatoprotective, antitubecular and antitumor properties. Both plants were extracted by ethanolic extract and administered to the test organism which is the albino rats. Experimental anf descriptive designs were employed in the study. Blood samples were quantified and qualified in a chosen laboratory in Antipolo, Rizal Percent reduction were used to determine the hepatoprotective activity of Bikas roots extract and Alagaw leaves extract to Albino rats after administration of treatments. Independent t-test was used to determine the significant difference between the rate of Hepatoprotective activity of Bikas roots and Alagaw leaves extract after its administration as well as the use of Sylimarin that serve as the positive control. Statistically, Alagaw shows better hepatoprotective activity compared to Sylimarin and Bikas. However, Alagaw and Bikas could be used as hepatoprotective supplement.