Animal experimentation : working towards a paradigm change / edited by Kathrin Herrmann, Kimberley Jayne.

Includes bibliographical references and index.

Foreword / Peter Singer - Preface ; Introduction / Kathrin Herrmann and Kimberley Jayne - Part 1. Why and how to shift the paradigm - Refinement on the way towards replacement: are we doing what we can? / Kathrin Herrmann - How to evaluate the science of non-human animal use in biomedical research and testing: a proposed format for debate / Ray Greek and Lisa A. Kramer - How can the final goal of completely replacing animal procedures successfully be achieved? / Christiane Baumgartl-Simons and Christiane Hohensee - Disease prevention with a plant-based lifestyle / Sabina V. Vyas - Part 2. Politics and legislation of animal experimentation - Political campaigning: where scientific and ethics arguments meet public policy / Emily McIvor - Rethinking the 3Rs: from whitewashing to rights / Charlotte E. Blattner - Contesting animal experiments through ethics and epistemology: in defense of a political critique of animal experimentation / Arianna Ferrari - Part 3. Openness in animal experimentation - The moral status of animal research subjects in industry: a stakeholder analysis / Sarah Kenehan - Increasing the transparency of animal experimentation: an Australian perspective / Monika Merkes and Rob Buttrose - Wasted money in United States biomedical and agricultural animal research / Jim Keen - Part 4. The ethics and philosophy of animal experimentation - Ethics, efficacy, and decision-making in animal research / Lawrence A. Hansen and Kori Ann Kosberg - Beyond plausibility checks: a case for moral doubt in review processes of animal experimentation / Mara-Daria Cojocaru and Philipp von Gall - Human wrongs in animal research: a focus on moral injury and reification / Jane Johnson and Anna Smajdor - Part 5. Effectiveness of the animal model - Critically evaluating animal research / Andrew Knight - Extrapolation of animal data to humans: an analysis of the evidence / Rebecca Ram - Is animal-based biomedical research being used in its original context? / Constança Carvalho, Daniel Alves, Andrew Knight and Luis Vicente - The scientific problems with using non-human animals to predict human responses to drugs and diseases / Ray Greek and Lisa A. Kramer - Replacing animals tests to improve safety for humans / Kathy Archibald, Robert Coleman and Tamara Drake - Genetic modification of animals: scientific and ethical issues / Jarrod Bailey - Animal research for Alzheimer Disease: failures of science and ethics / John J. Pippin, Sarah E. Cavanaugh Francesca Pistollato - Behavioral research on captive animals: scientific and ethical concerns / Kimberley Jayne and Adam See - Part 6. Animal-free education and training - Modernizing biomedical training: replacing live animal laboratories with human simulation / John Pawlowski, David Feinstein, Marie L. Crandall and Shalin Gala - Humane education: the tool for scientific revolution in Brazil / Vanessa Carli Bones [and others] - Part 7. Paradigm shift: advanced animal-free approaches - Recent developments in alternatives to animal testing / Katy Taylor - The changing paradigm in preclinical toxicology: in vitro and in silico methods in liver toxicity evaluations / Fozia Noor - The potential of organ on chip technology for replacing animal testing / Malcolm Wilkinson - When is an alternative not an alternative? Supporting progress for absolute replacement of animals in science / Craig Redmond - Research and testing without animals: where are we now and where are we heading? / Thomas Hartung - Afterword: evidence over interests / John P. Gluck.

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Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science.

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