Histamine H4 receptor: a Novel Drug Target For Immunoregulation and Inflammation

Holger Stark

Open Access Published by De Gruyter Open Poland 2014

Histamine H4 receptor

a Novel Drug Target For Immunoregulation and Inflammation

Holger Stark

https://doi.org/10.2478/9788376560564

Overview
Contents

About this book

H₄ R is the newest member of the histamine receptor family, which was discovered about twelve years ago. It is considered a very promising drug target. The effort to improve the pharmacokinetic properties of the currently available H₄ R ligands is reflected in a steadily growing number of scientific publications and patent applications. Preclinical data strongly confirms the need for novel potent H₄ R ligands to explore their therapeutic value in allergy, inflammation, autoimmune disorders, and possibly, cancer.
Readers will be provided with extensive knowledge on histamine metabolism, as well as cellular histamine transport, storage and release, effects of histamine and histamine receptor ligands, with particular attention to the H₄ R, on inflammatory cells including mast cells, basophils, eosinophils, neutrophils, macrophages, dendritic cells, and T cells. The present knowledge on the regulatory role of histamine and the therapeutic exploitation of histamine receptor ligands in atopic diseases, with emphasis on human and animal models of asthma, allergic dermatitis and pruritus are discussed.

G protein coupled receptors, Histamine H₄R ligands, Inflammation and Autoimmune Disorders

Author / Editor information

Holger Stark, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.

Topics

Frontmatter Publicly Available Download PDF	1
Contents Publicly Available Download PDF	5
Preface Publicly Available Download PDF	13
Chapter 1 The histamine H₄ receptor story Publicly Available Download PDF	15
Chapter 2 Histamine H₄ Receptor Ligands Publicly Available Download PDF	21
Chapter 3 Histamine Metabolism Publicly Available Download PDF	63
Chapter 4 Histamine Receptors and Inflammatory Cells Publicly Available Download PDF	103
Chapter 5 Histamine in Asthmatic and Fibrotic Lung Disorders Publicly Available Download PDF	145
Chapter 6 Histamine in Atopic Disorders: Atopic Dermatitis and Pruritus Publicly Available Download PDF	173
Chapter 7 Non-professional Histamine Producing Cells, Immune Responses and Autoimmunity Publicly Available Download PDF	201
Chapter 8 Histamine in Cancer Publicly Available Download PDF	259
Chapter 9 Non Receptor-mediated Histamine Actions Publicly Available Download PDF	309
Chapter 10 Perspectives in H₄R Research and Therapeutic Exploitation Publicly Available Download PDF	333
List of Figures Publicly Available Download PDF	353
List of Tables Publicly Available Download PDF	361
Index Publicly Available Download PDF	363

(Deutsch)

Language: English
Publisher: De Gruyter Open Poland
Audience: Academic Researchers in Life Sciences, Researchers in Big Pharma, Pharmacologists
Pages
- Main content: 368
Illustrations
- Illustrations: 31
- Coloured Illustrations: 23
- Tables: 13
Keywords: G protein coupled receptors; H4R ligands; Inflammation; Autoimmune Disorders; Pruritus; Asthma; Allergy; Cancer; Drug Development; Drug Target; Clinical Candidates; Biogenic Amin

eBook

Published: November 20, 2013
ISBN: 9788376560564

Hardcover

Published: December 2, 2013
ISBN: 9788376560557